Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Neural Circuits01:25

Neural Circuits

2.5K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
2.5K
Somatosensory, Motor, and Association Cortex01:24

Somatosensory, Motor, and Association Cortex

2.0K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
2.0K
Propagation of Action Potentials01:23

Propagation of Action Potentials

8.5K
The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
8.5K
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

6.6K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
6.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.

Nature methods·2026
Same author

Topographic structure and function of locus coeruleus norepinephrine neurons.

bioRxiv : the preprint server for biology·2026
Same author

Functional reorganization of motor cortex connectivity during learning.

bioRxiv : the preprint server for biology·2026
Same author

Eating Disorders Prevention and Management Among Australian and New Zealand Dietetic Professionals: A Repeat Cross-Sectional Study Exploring Training Needs and Future Opportunities.

The International journal of eating disorders·2026
Same author

Evaluation of a machine learning system for genomic antimicrobial susceptibility determination on a clinically representative test set.

Microbiology spectrum·2026
Same author

To remap or not remap: Experience matters.

Cell reports·2026
Same journal

Six ways to put the public at the heart of science and policy.

Nature·2026
Same journal

The complex truth about trust in science.

Nature·2026
Same journal

Have people stopped trusting science? The data tell a surprising story.

Nature·2026
Same journal

How FAIR data are helping to build trust in science.

Nature·2026
Same journal

Scientists should recognize their own political biases to build public trust.

Nature·2026
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
関連記事をすべて見る

関連する実験動画

Updated: Dec 27, 2025

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations
10:45

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

Published on: June 14, 2020

7.9K

局所的な皮質回路における反復的相互作用

Simon Peron1,2, Ravi Pancholi3, Bettina Voelcker3

  • 1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. speron@nyu.edu.

Nature
|March 6, 2020
PubMed
まとめ
この要約は機械生成です。

脳内の局所的な回路は 感覚信号を放大しますが 特定のニューロンサブネットワーク内でのみです これらのサブネットワークを妨害すると 触覚表現が著しく損なわれ 感覚処理における重要な役割が強調されます

さらに関連する動画

Examining Local Network Processing using Multi-contact Laminar Electrode Recording
13:40

Examining Local Network Processing using Multi-contact Laminar Electrode Recording

Published on: September 8, 2011

13.1K
Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

1.2K

関連する実験動画

Last Updated: Dec 27, 2025

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations
10:45

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

Published on: June 14, 2020

7.9K
Examining Local Network Processing using Multi-contact Laminar Electrode Recording
13:40

Examining Local Network Processing using Multi-contact Laminar Electrode Recording

Published on: September 8, 2011

13.1K
Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

1.2K

科学分野:

  • 神経科学
  • 計算神経科学
  • システム神経科学

背景:

  • 皮質のシナプスは主に局所的で刺激性であり,増幅やパターンの完成などの計算を可能にする再帰回路を形成する.
  • 皮質回路は,接続性が向上したサブネットワークと類似した受容領域を特徴としていますが,その機能は,神経集団が混ざり合っているため,探知することは困難です.
  • 特定の皮質層における再帰結合の役割を理解することは 感覚処理メカニズムの解読に不可欠です

研究 の 目的:

  • マウスの振動性体感皮質の2/3層における再発的結合の機能を,アクティブな触覚的差別で調査する.
  • 特定の皮質サブネットワーク内の感覚信号増幅に,再発的な刺激がどのように影響するかを決定する.
  • 増幅されたサブネットワークの標的ニューロンアブレーションに対する感受性をテストする.

主な方法:

  • 繰り返しの興奮と増幅をシミュレートするために,層2/3の計算神経回路モデルを開発した.
  • マウスの振動性体感皮質の光学記録と標的型光分解を用いた.
  • 特定の触覚入力を表すマッピングされたニューロン選択性と選択的に切除されたニューロン.

主要な成果:

  • 再帰刺激は,特に接続性の向上によって特徴づけられるサブネットワーク内の感覚信号を増幅します.
  • 高増幅のモデルネットワークは,サブネットワークメンバーのシミュレートされた損失で劣化した刺激エンコーディングを示した.
  • 触覚を表現するニューロンの少数の実験的な切除は,保存された触覚表現における応答を著しく減少させ,モデル予測を確認した.

結論:

  • 類似の選択性を持つ皮質ニューロン間の再発は,行動中に入力特有の信号増幅を促します.
  • これらの増幅されたサブネットワークは,正確なセンサリーエンコーディングに不可欠であり,標的の干渉に敏感です.
  • 発見は哺乳類の皮質における 感覚処理と計算の鍵となるメカニズムを明らかにしています