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Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

11.0K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
11.0K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

11.9K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
11.9K
Olfaction01:25

Olfaction

47.9K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
47.9K
Introduction to Special Senses01:26

Introduction to Special Senses

7.2K
Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
7.2K
Introduction to Sensory Receptors01:31

Introduction to Sensory Receptors

7.4K
Sensory receptors are vital in our ability to perceive and interpret the world. Sensory receptors are specialized cells in the peripheral nervous system that respond to various stimuli and enable one to experience different sensations. Based on specific criteria, sensory receptors are classified into distinct types.
The first classification criterion is based on cell type, position, and function. Some receptor cells are neurons with free nerve endings, where their dendrites are embedded in the...
7.4K
Tactile and Chemical Senses01:27

Tactile and Chemical Senses

624
Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex.
624

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関連する実験動画

Updated: Dec 27, 2025

Multi-unit Recording Methods to Characterize Neural Activity in the Locust Schistocerca Americana Olfactory Circuits
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Multi-unit Recording Methods to Characterize Neural Activity in the Locust Schistocerca Americana Olfactory Circuits

Published on: January 25, 2013

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嗅覚受容体と回路の進化は宿主特化を促進する

Thomas O Auer1, Mohammed A Khallaf2, Ana F Silbering3

  • 1Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. Thomas.Auer@unil.ch.

Nature
|March 6, 2020
PubMed
まとめ

フルーツ・フライ (Drosophila sechellia) の進化,特に宿主探しについて調査した. 研究者達はノニの果実への魅力を裏付ける 遺伝的・神経的変化を特定し 種化と神経系進化の洞察を明らかにしました

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Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
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Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Published on: April 23, 2019

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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay

Published on: October 2, 2017

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関連する実験動画

Last Updated: Dec 27, 2025

Multi-unit Recording Methods to Characterize Neural Activity in the Locust Schistocerca Americana Olfactory Circuits
12:13

Multi-unit Recording Methods to Characterize Neural Activity in the Locust Schistocerca Americana Olfactory Circuits

Published on: January 25, 2013

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Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
09:53

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay

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科学分野:

  • 神経遺伝学
  • 進化生物学
  • 動物 の 行動

背景:

  • 動物の行動進化の遺伝的根拠は 十分に理解されていない.
  • 種間の行動の違いの遺伝的基盤を証明する研究はほとんどありません.

研究 の 目的:

  • ドロソフィラ・セセリアの 行動的差異の 神経遺伝的根拠を調査する
  • 種特有の宿主探し行動を 誘導する分子と神経のメカニズムを特定する

主な方法:

  • ドロソフィラ・セセリアの嗅覚経路を特定するためにカルシウム画像を用いた.
  • 嗅覚受容体での変異分析と 異種間のアレル移転実験を行いました
  • ドロソフィラ・セセリアの脳で サーキット・トラッキングを行いました

主要な成果:

  • 特定された特定の嗅覚受容体は,ノニの果実への長距離および短距離の魅力を決定する.
  • 嗅覚受容体の調整が 種特有の宿主探求の鍵であることを示した.
  • 神経の適応や 感覚の結合や 投影パターンの変化が 感受体の変化に伴っていることが分かりました

結論:

  • 分子,生理,解剖学的特徴の 蓄積が 行動の分岐を誘発している
  • ドロソフィラ・セセリアを種化と神経系の進化を研究するモデルシステムとして確立した.