関連する実験動画

Updated: Dec 26, 2025

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

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DNAダメージによるRNAPIIのユビキチネーションは,転写結合修復を促進する

Yuka Nakazawa1, Yuichiro Hara1, Yasuyoshi Oka1

  • 1Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Cell
|March 7, 2020
PubMed
まとめ

RPB1-K1268におけるRNAPIIのユビキチネーションは,DNA修復と転写回復に不可欠である. このプロセスは,停滞したRNAポリメラーゼIIを解除することによって,早めの老化および神経変性から保護します.

キーワード:
CRL/CSA/CSBについてCS についてCHIP-seq についてコケイン症候群NER についてRNAポリメラーゼIIRNAPII についてTCR についてTFIIH について紫外線感受症候群UVSSAUVsS について核酸切除修復トランスクリプション・カップル・リペアRNAPIIのユビキチン化

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