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Updated: Dec 26, 2025

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心血管疾患に関連した腸内微生物代謝物は,アドレナージック受容体を通して作用する

Ina Nemet1, Prasenjit Prasad Saha1, Nilaksh Gupta1

  • 1Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.

Cell
|March 7, 2020
PubMed
まとめ

新たに発見された腸内微生物の代謝物であるフェニラセチルグルタミン (PAGln) は,血小板活性化と血栓形成を強めることで,心血管疾患 (CVD) を促進する. この代謝物は アドレナゲン受容体を通して信号を送り 心血管疾患の予防に新たな標的となる可能性がある.

キーワード:
GPCR についてアドレナゲン受容体心血管疾患腸内微生物メタボロミクストロンボシス

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