白血球 と 血圧: メンデルの ランダム化 研究
Mateusz Siedlinski1,2, Ewelina Jozefczuk1, Xiaoguang Xu3
1Department of Internal and Agricultural Medicine, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland (M.S., E.J., T.J.G.).
Circulation
|March 10, 2020
まとめ
高血圧はリンパ球数の増加と関連しています. 遺伝子解析はリンパ球数と血圧の因果関係を示唆し,高血圧に関する新しい洞察を提供している.
科学分野:
- 免疫学
- 遺伝学
- 心血管医学
背景:
- 高血圧 (BP) は心臓血管疾患の主要な危険因子です.
- 腎臓,血管,交感神経系が 血圧を調節する一方で 免疫細胞の役割が 明らかになっています
- 最近のデータは,免疫細胞が高血圧の発生に影響を及ぼすことを示唆している.
研究 の 目的:
- 白血球と血圧の関連性を調べるため
- メンデルのランダム化 (MR) を使用して白血球集団がBPと因果的に関連しているかどうかを決定する.
主な方法:
- イギリスのバイオバンクで 白血球数と血圧を研究しました
- UK Biobank/International Consortium of Blood Pressure-Genome-Wide Association Studiesから約75万人の参加者を対象にMR分析を実施した.
- 121の単一ヌクレオチドポリモルフィズムと逆変数加重アプローチをMR分析に使用した.
主要な成果:
- リンパ球数,単細胞数,中性粒子の数と静脈動脈動脈圧の上昇 (P< 10- 50) の間の正の関連が観察されました.
- リンパ球数とシストリック/ダイアストリックBP (1 SD遺伝的に増加した数値に対してそれぞれ0. 69mmHg) の間の潜在的な因果関係をMRが特定した.
- リバースMRでは,単細胞,中性細胞,エオシノフィルの数値に対するBP効果が示されましたが,リンパ細胞や基礎細胞は示されませんでした.
結論:
- 観察的および遺伝的分析は,リンパ球数とBPの間の一致し,陽性であり,潜在的に因果的な関係を確認しています.
- 研究結果は高血圧におけるリンパ球の役割を強調しています.
- 免疫細胞を標的とする治療法について,さらなる研究が進められるでしょう.
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