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Updated: Dec 26, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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NOTCHシグナリングに収束する頭頸状細胞がんの希少なドライバー変異

Sampath K Loganathan1, Krista Schleicher1,2, Ahmad Malik1,2

  • 1Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

Science (New York, N.Y.)
|March 14, 2020
PubMed
まとめ

研究者らは,頭頸部状細胞癌 (HNSCC) を抑制するADAM10とAJUBAを含む15の腫瘍抑制遺伝子を特定しました. これらの遺伝子はNOTCH受容体のシグナル伝達を促進し,その不活性化はHNSCCの特徴です.

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In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands05:48

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

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