Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Isomerism02:43

Isomerism

22.8K
Isomers are molecules with the same molecular formula but different structural arrangements. Isomers can be further classified into constitutional isomers and stereoisomers. Constitutional isomers differ in the connectivity of their constituent atoms. For example, 2-butanol and diethyl ether are constitutional isomers, as they have the same chemical formula, C4H10O, but differ in the connectivity of the carbon and oxygen atoms. Constitutional isomers have different physical and chemical...
22.8K
Stereoisomerism02:52

Stereoisomerism

13.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
13.7K
Stereoisomers02:32

Stereoisomers

17.3K
On the basis of mirror symmetry, stereoisomers of an organic molecule can be further classified into diastereomers and enantiomers. Diastereomers are stereoisomers that are not mirror images of each other. Substituted alkenes, such as the cis and trans isomers of 2-butene, are diastereomers, as these molecules exhibit different spatial orientations of their constituent atoms, are not mirror images of each other, and do not interconvert. Here, the interconversion is suppressed due to...
17.3K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

10.8K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
10.8K
Structural Isomerism02:34

Structural Isomerism

21.4K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
21.4K
Constitutional Isomers of Alkanes02:18

Constitutional Isomers of Alkanes

21.6K
Organic compounds of the same molecular formula can have different structural formulas called constitutional isomers, and the phenomenon is known as constitutional isomerism. Alkanes with four or more carbons showing multiple structures with the same molecular formula thereby exhibit constitutional isomerism.
The linear isomer of an alkane is prefixed by the term “n”; hence a linear isomer of pentane is known as n-pentane. Based on the type of branching, some of the...
21.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

A Highly Sensitive PSMA-Targeted Ratiometric NIR Probe for Rapid Imaging of Prostate Cancer Acidity in Living Mice.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

<i>Z</i>-Selective semihydrogenation of alkynes via Ni/Lewis acid synergistic catalyzed system using DMF as hydrogen source and solvent.

Beilstein journal of organic chemistry·2026
Same author

Impact of iGlarLixi on Glycaemic Control Depth and Variability in Asian Pacific People With Type 2 Diabetes: A Post Hoc Analysis of LixiLan-O-AP and LixiLan-L-CN.

Diabetes, obesity & metabolism·2026
Same author

Colorectal Cancer Progression and Bone Metastasis: Molecular Mechanisms, Tumor Microenvironment, and Tumor-Bone Crosstalk.

Cancer management and research·2026
Same author

A single-arm prospective phase I trial of 68Ga-PFBC01 PET/CT for multiple myeloma B cell maturation antigen imaging.

The Journal of clinical investigation·2026
Same author

Efficient Extraction of Nicotine From Tobacco Absolute Oil by Ionic Liquid-Decorated Boron Nitride/Poly(N-isopropylacrylamide) Composite Hydrogel.

Journal of separation science·2026

関連する実験動画

Updated: Dec 26, 2025

Synthesis and Structure Determination of &#181;-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

13.0K

分割と使用:診断と治療のための構造的同位体

Yingying Ning1, Yi-Wei Liu1, Zi-Shu Yang1

  • 1Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.

Journal of the American Chemical Society
|March 17, 2020
PubMed
まとめ

この研究は,関連したポルフィルノイド・レジオイソマーを用いた新しいセラノスティックアプローチを導入しています. 1つの同位体は近赤外線画像処理を可能にし,もう1つは光ダイナミック療法 (PDT) を促進し,統合診断と治療のための新しい戦略を提供します.

さらに関連する動画

Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
09:54

Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes

Published on: September 12, 2018

8.1K
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

7.2K

関連する実験動画

Last Updated: Dec 26, 2025

Synthesis and Structure Determination of &#181;-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

13.0K
Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
09:54

Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes

Published on: September 12, 2018

8.1K
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

7.2K

科学分野:

  • * 薬剤化学と分子イメージング
  • * ナノテクノロジーと生物医学工学

背景:

  • * 現在のセラノスティック剤は,しばしば複雑な合成と,診断と治療のための異なった用量要求を伴う.
  • * 診断機能と治療機能を単一の分子単位に統合することは,医学において重要な課題です.

研究 の 目的:

  • * 密接に関連したポルフィルノイド・レジオイソマーを用いた新しいセラノスティック戦略を開発する.
  • * これらのレジオアイソマーとそのイテルビウム (III) 複合体の独特の診断および治療能力を実証する.

主な方法:

  • * 1,3-二極サイクロアディションによるポーリノイド・レジオアイソマーの合成.
  • 診断と治療のためのイテルビウム (III) 複合体の形成.
  • * 画像と光ダイナミック療法の有効性のインビトロおよびインビボ評価

主要な成果:

  • * *cis*同位体は,そのイテルビウム (III) 複合体として,近赤外線 (NIR) 画像に適した発光性を表している.
  • *トランス*同位体は,そのイテルビウム (III) 複合体として,光力学療法 (PDT) のシングレット酸素を効果的に生成し,良好な量子産出率を有する.
  • * 両方の同位体には補完的な生物学的機能があり, in vitro 及び in vivo 実験で検証された.

結論:

  • * 密接に関連したポルフィリノイド・レジオイソマーを分離して,異なる診断 (イメージング) と治療 (PDT) 機能を果たすことができる.
  • * この研究は,効果的なセラノスティックアプリケーションのためのペアリングされた分子セットを作成するための新しいパラダイムを提示します.
  • * この発見は,同位体化合物を用いた診断と治療の方法の切り替えにおける多面的なアプローチを強調しています.