COVID-19 と 心血管疾患
Kevin J Clerkin1, Justin A Fried1, Jayant Raikhelkar1
1Department of Medicine, Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York.
Circulation
|March 24, 2020
まとめ
2019年新型コロナウイルス病 (COVID-19) は,重症急性呼吸器症候群新型コロナウイルス2 (SARS-CoV-2) が心血管の健康に影響を与えている. 治療法や心臓移植の課題については さらに研究が必要です
科学分野:
- 心臓病科
- 感染症
- ウイルス学
背景:
- 2019年コロナウイルス病 (COVID-19) は,SARS-CoV-2によって引き起こされる世界的なパンデミックです.
- SARS-CoV-2は,アニオテンシン変換酵素2 (ACE2) 受容体を細胞への侵入に利用する.
- COVID-19は,既にある心血管疾患の患者に著しく影響を及ぼし,心筋損傷の有意な流行があります.
研究 の 目的:
- COVID-19の病原性におけるACE2の役割を調査する.
- COVID-19患者のACE阻害剤 (ACEi) と血管新生素受容体阻害剤 (ARB) の影響を調査する.
- COVID-19が心臓移植に 与える課題に対処するためです
主な方法:
- COVID-19,SARS-CoV-2,および心血管への影響に関する現在の文献のレビュー.
- 心筋損傷とACE2受容体の関与に関する患者のデータ分析
- 治療戦略と移植プロトコルの議論
主要な成果:
- COVID-19患者の心血管疾患および心筋損傷の高流行.
- ACE2受容体は,SARS-CoV-2の主なエントリーポイントとして特定されました.
- COVID-19管理における ACEiとARBの役割については,依然として不確実性があります.
- COVID-19は心臓移植におけるドナーの選択,免疫抑制,移植後のケアを複雑にします.
結論:
- COVID-19は心筋損傷を含む心臓血管の健康に重大なリスクをもたらします.
- ACE2の感染における役割と関連する薬剤の影響については,さらなる調査が必要である.
- 心臓移植プロトコルは,COVID-19に感染した患者の管理に適応する必要があります.
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