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Updated: Dec 25, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
08:14

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

8.5K

静脈血栓塞栓症のリスクに対するPCSK9 (プロプロテインコンバーターゼサブチリシン/ケキシン型9) 抑制の効果

Nicholas A Marston1, Yared Gurmu1, Giorgio E M Melloni1

  • 1TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (N.A.M., Y.G., G.E.M.M., B.G., M.L.O., R.P.G., C.T.R., M.S.S.).

Circulation
|April 1, 2020
PubMed
まとめ

静脈血栓塞栓症 (VTE) のリスクを,特に1年を超えて大幅に低下させる. リポプロテインのレベルと遺伝的リスクスコアは,この治療から最も恩恵を受ける患者を特定します.

キーワード:
ヒトのPCSK9タンパク質コレステロール,LDLエボロキュマブ治療に必要な人数静脈血栓塞栓症

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