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Updated: Dec 25, 2025

A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters
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A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters

Published on: April 20, 2015

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CLCの分子基礎 フッ素によるアンチポーター阻害

Maria Gabriella Chiariello1,2, Viacheslav Bolnykh3, Emiliano Ippoliti1,2

  • 1Institute for Advanced Simulation (IAS-5) and Institute of Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, 52425 Jülich, Germany.

Journal of the American Chemical Society
|April 3, 2020
PubMed
まとめ

フッ素は,E. coli ClC-ec1の選択性フィルターに陽子を結合することによって,塩化チャネル機能を阻害する. この相互作用はタンパク質の形状を変えることで 陽子輸送を妨げます

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