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Updated: Dec 25, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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Published on: January 31, 2018

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DNA断裂におけるアロステリックPARP-1保持の構造的基礎

Levani Zandarashvili1, Marie-France Langelier2, Uday Kiran Velagapudi3

  • 1Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Science (New York, N.Y.)
|April 4, 2020
PubMed
まとめ

ポリ ((ADP-リボース) ポリメラーゼ-1 (PARP-1) 阻害剤は,DNAの破裂時にPARP-1を捕まえる. 研究者はPARP-1を抑制する新しい阻害剤を開発し,がん細胞の殺戮を強化し,新しい臨床的選択肢を提供しました.

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