組織特異的な薬物投与のための標的化戦略
Zongmin Zhao1, Anvay Ukidve1, Jayoung Kim1
1John A. Paulson School of Engineering and Applied Sciences, Harvard University, MA 02138, USA; Wyss Institute of Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
Cell
|April 4, 2020
まとめ
標的化戦略は,局所特有の投与を可能にし,生物学的障壁を克服し,標的外効果を軽減することによって,薬剤の有効性を改善します. このレビューでは,小分子,核酸,ペプチド,抗体,および組織特異的な薬物投与のための細胞ベースのアプローチの進歩について論じています.
科学分野:
- 薬理学について
- 薬物の配達
- 生物医学工学
背景:
- 薬剤の全身投与は,治療効果と毒性に影響を与える,標的外効果の課題に直面しています.
- 生物学的障壁により 組織特異的な薬剤の投与が妨げられ 先進的な戦略が必要になります
- これらの障壁を克服することは より安全で効果的な治療法の開発に不可欠です
研究 の 目的:
- 組織特異薬剤投与における主要な進歩と新興概念をレビューする.
- 生物学的障壁を克服するための戦略を議論する.
- 様々な薬剤標的化アプローチの臨床的翻訳を探求する.
主な方法:
- 薬物ターゲティング戦略に関する臨床前および臨床研究の文献レビュー.
- 小分子,核酸,ペプチド,抗体,細胞ベースの伝達システムの分析.
- 生物学的障壁とそれを克服する方法を議論する.
主要な成果:
- 複数のターゲティング戦略が30年にわたって開発されました.
- これらの戦略には,小分子,核酸,ペプチド,抗体,細胞ベースのアプローチが含まれます.
- 特定の組織に対する薬物の投与を調節するうえで 顕著な進展がみられた.
結論:
- 組織特異的な薬の投与は,非標的効果と毒性を減らすために有望である.
- 治療の進歩には 生物学的障壁を克服する研究が不可欠です
- これらのターゲティング戦略を臨床実用化することは 将来の薬物開発の重要な焦点です
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