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Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
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ドーパミニル化ヒストンH3は,腹膜領域におけるコカイン探求を調節する

Ashley E Lepack1, Craig T Werner2, Andrew F Stewart1

  • 1Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Science (New York, N.Y.)
|April 11, 2020
PubMed
まとめ

コカイン中毒は ヒストンの改変によって 脳の遺伝子発現を変化させます 腹部タグメンタル領域 (VTA) のヒストンH3グルタミン5ドパミニレーション (H3Q5dop) の減少は,これらの変化を逆転させ,コカイン探求を減少させた.

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