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Updated: Dec 24, 2025

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

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異常な連鎖融合ポリケチド,グレガチンAの生物合成の分子基礎

Wei-Guang Wang1, Hang Wang2, Lian-Qiong Du1

  • 1Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, Yunnan, China.

Journal of the American Chemical Society
|April 11, 2020
PubMed
まとめ

研究者らは,真菌のポリケチドグレガチンAの生物合成を明らかにした. 単一のポリケチド合成酵素とユニークなヒドロラーゼ酵素が2つの異なるポリケチド鎖を融合させ,新しい生物合成戦略を明らかにした.

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The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli10:41

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