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Updated: Dec 24, 2025

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
08:47

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation

Published on: March 5, 2018

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空間時的アポトーシス誘導のための分子接着剤によるカスパース-3の細胞内光活性化

Nina B Hentzen1, Rina Mogaki2, Saya Otake2

  • 1Laboratorium für Organische Chemie, ETH Zürich, D-CHAB, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.

Journal of the American Chemical Society
|April 11, 2020
PubMed
まとめ

新しい分子接着剤であるPC-Glueは,アポトーシス誘発酵素Casp-3 (Casp-3) を細胞に放出する. 発光するとCasp-3が放出され 標的細胞のプログラム細胞死亡を 精密に制御できます

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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