2019年コロナウイルス病 (COVID-19) の薬理学的治療法:レビュー
James M Sanders1,2, Marguerite L Monogue1,2, Tomasz Z Jodlowski3
1Department of Pharmacy, University of Texas Southwestern Medical Center, Dallas.
JAMA
|April 14, 2020
まとめ
2019年新型コロナウイルス病 (COVID-19) の有効な治療法はまだ証明されていません. 進行中の臨床試験は,重症急性呼吸器症候群コロナウイルス2 (SARS-CoV-2) パンデミックと闘うための有効な治療法を特定するために重要である.
科学分野:
- ウイルス学
- 感染症
- 公衆衛生
背景:
- SARS-CoV-2によって引き起こされる新型コロナウイルス感染症2019 (COVID-19) は,世界的な健康上の大きな課題となっています.
- 有効な治療法と予防薬が緊急に必要です
研究 の 目的:
- COVID-19の有効な治療法に関する現在の証拠をレビューする.
- SARS-CoV-2 感染に対する有望な治療標的と治療剤を特定する.
主な方法:
- 現在の科学文献と進行中の臨床試験データをレビューする.
- レムデシビル,オセルタミビル,コルチコステロイドを含む潜在的な治療法の有効性の評価
- COVID-19のアウトカムに対する既存の状態と薬剤 (ACE阻害剤,ARB) の影響の評価.
主要な成果:
- これまでのところ,SARS-CoV-2に対する有効性が証明された治療法はありません.
- レムデシビルには in vitro の活性があるが,ランダム化試験でのさらなる評価が必要である.
- オセルタミビルは無効であり,コルチコステロイドは推奨されません.現在の証拠は,ACE阻害剤またはARBの中止を支持しません.
結論:
- COVID-19 パンデミックは,迅速な証拠生成を必要とする主要な世界的な健康危機です.
- 臨床試験の迅速な開始は,パンデミック中に高品質のデータを生成する能力を示しています.
- COVID-19の効果的な治療法を確立するには,さらなる研究が不可欠です.
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