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Updated: Dec 24, 2025

Inducible LAP-tagged Stable Cell Lines for Investigating Protein Function, Spatiotemporal Localization and Protein Interaction Networks
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LRP1は,タウの吸収と拡散の主なレギュラーである

Jennifer N Rauch1, Gabriel Luna1, Elmer Guzman1

  • 1Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA.

Nature
|April 17, 2020
PubMed
まとめ

低密度リポプロテイン受容体関連タンパク質1 (LRP1) は,神経変性疾患におけるタウタンパク質集合体の拡散を制御する. LRP1を阻害すると,タウの吸収と伝播が低下し,タウ病に対する潜在的な治療標的となる.

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