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Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Protein Networks02:26

Protein Networks

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Protein-protein Interfaces02:04

Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein-Protein Interfaces02:04

Protein-Protein Interfaces

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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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Updated: Dec 24, 2025

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells
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Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

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人間のバイナリタンパク質インタラクトームの参照地図

Katja Luck1,2,3, Dae-Kyum Kim1,4,5,6, Luke Lambourne1,2,3

  • 1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.

Nature
|April 17, 2020
PubMed
まとめ
この要約は機械生成です。

研究者らは5万3000の相互作用をマッピングした 人間タンパク質相互作用ネットワーク (HuRI) を作成しました この包括的なインタラクトームマップは,ゲノタイプ-フェノタイプ関係と細胞機能の理解を助けます.

さらに関連する動画

Mapping Dysfunctional Protein-Protein Interactions in Disease
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Mapping Dysfunctional Protein-Protein Interactions in Disease

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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

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関連する実験動画

Last Updated: Dec 24, 2025

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells
08:38

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

Published on: March 3, 2015

13.8K
Mapping Dysfunctional Protein-Protein Interactions in Disease
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Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

423
Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

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科学分野:

  • 分子生物学
  • ゲノミクス
  • システム生物学

背景:

  • 細胞組織とゲノム機能を理解することは,遺伝子型とフェノタイプを結びつけるのに不可欠です.
  • 既存のタンパク質相互作用のデータは,規模と範囲が限られている.

研究 の 目的:

  • HuRI と呼ばれる包括的なヒト"すべて"参照インタラクトームマップを提示する.
  • 様々な生理学的および病理学的文脈における細胞機能の研究を,ゲノム,トランスクリプトミク,およびプロテオミクデータを統合することによって可能にする.

主な方法:

  • ヒトのバイナリタンパク質-タンパク質相互作用マップ (HuRI) の構築.
  • HuRIマップとゲノム,トランスクリプトーム,タンパク質のデータセットの統合.
  • HuRIマップからの組織特有のネットワークの推論.

主要な成果:

  • HuRIには約53,000のヒトのバイナリタンパク質相互作用があり,既存のキュレーションされたデータセットを大幅に拡張しています.
  • タンパク質とタンパク質の相互作用の特定のサブセルラー役割を特定する上でHuRIの有用性を実証した.
  • 推論された組織特異的なネットワークは,細胞の文脈特異的な機能の原理とメンデルの疾患の潜在的なメカニズムを明らかにした.

結論:

  • HuRIは,ヒトのタンパク質の相互作用のための体系的な,プロテオーム全体の参照マップとして機能します.
  • この地図は,ゲノタイプ-フェノタイプ関係と細胞機能の研究を容易にする.
  • HuRIは,組織特異的な表型と疾患の背後にある分子機構を明らかにするのに役立ちます.