関連する実験動画

Updated: Dec 23, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

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一つの細胞分裂の誤りからがんゲノムの複雑性を生み出すメカニズム

Neil T Umbreit1,2,3, Cheng-Zhong Zhang4,5, Luke D Lynch2,3

  • 1Howard Hughes Medical Institute, Chevy Chase, MD, USA. neilt_umbreit@dfci.harvard.edu david_pellman@dfci.harvard.edu cheng-zhong_zhang@dfci.harvard.edu.

Science (New York, N.Y.)
|April 18, 2020
PubMed
まとめ

細胞分裂エラーによって引き起こされる染色体破裂融合ブリッジ (BFB) サイクルは,がんにおける遺伝子増幅とゲノム不安定を誘発する. このプロセスには アクトミオシンとDNA複製が関与し クロモトリプシスと癌の進化を促します

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