関連する実験動画

Updated: Dec 23, 2025

Capturing Common Fragile Site Breaks by Native γH2A.X ChIP
09:46

Capturing Common Fragile Site Breaks by Native γH2A.X ChIP

Published on: January 24, 2025

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ヘテロクロマチン駆動による核軟化が,機械的ストレスによる損傷からゲノムを保護する

Michele M Nava1, Yekaterina A Miroshnikova1, Leah C Biggs2

  • 1Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland; Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany; Cologne Excellence Cluster for Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.

Cell
|April 18, 2020
PubMed
まとめ

細胞はクロマチンの変化によって 核を柔らかくすることで 機械的なストレスからゲノムを守ります 組織は力を減らし DNAの損傷を防止し ホメオスタシスを維持するために調整します

キーワード:
DNA 損傷クロマチンヘテロクロマチンメカノプロテクションメカニカルトランスデュークション核建築核ラミナ核力学幹細胞

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