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Updated: Dec 23, 2025

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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バイアスヘトロトリマー安定化による選択的PP2A強化

Daniel Leonard1, Wei Huang2, Sudeh Izadmehr3

  • 1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Cell
|April 22, 2020
PubMed
まとめ

新しい分子であるDT-061は,B56α-PP2A酵素を安定させ,c-Mycのようながん標的に対する活性性を高めます. この発見は,タンパク質フォスファタゼ2A (PP2A) 機能障害を含む疾患に対する新しい治療戦略を提供します.

キーワード:
B56αPP2A についてスマップc-マイク癌についてクリオ・エムリン酸塩小分子

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