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Updated: Dec 23, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Published on: February 20, 2018

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メラノコルチン-4受容体の構造の決定は,リガンド結合のためのコファクターとしてCa2+を識別する

Jing Yu1,2,3, Luis E Gimenez4, Ciria C Hernandez4

  • 1iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.

Science (New York, N.Y.)
|April 25, 2020
PubMed
まとめ

研究者は,抗体と結合するメラノコルチン-4受容体 (MC4R) の構造を決定した. カルシウムイオン (Ca2+) は,アゴニスト結合とシグナル伝達を強化する重要なコファクターであることが判明しました.

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