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Updated: Dec 23, 2025

Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells
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Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells

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再プログラムされた遺伝子コードmRNAディスプレイによる強力なサイクルスルフォペプチドケモキン阻害剤の発見

Jason Johansen-Leete1, Toby Passioura1,2,3,4, Simon R Foster5

  • 1School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.

Journal of the American Chemical Society
|April 25, 2020
PubMed
まとめ

炎症性ケモカインシグナルを 標的とするチロシン硫酸サイクルペプチドを開発しました これらの新しいペプチドは,CCL11 (エオタキシン-1) に強く結合し,その受容体の活性化を阻害し,炎症性疾患に対する新しい治療方法を提供します.

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Peptide-based Identification of Functional Motifs and their Binding Partners

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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