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呼吸器複合体Iにおける電荷移転と化学機械結合

Chitrak Gupta1,2, Umesh Khaniya3,4, Chun Kit Chan5

  • 1School of Molecular Sciences, Arizona State University, Tempe, Arizona 85281, United States.

Journal of the American Chemical Society
|April 30, 2020
PubMed
まとめ

分子ダイナミクスのシミュレーションにより,Thermus thermophilusの複合体Iが酸化還元反応と陽子ポンプをどのように結びつけるかを明らかにした. この研究は,ミトコンドリアの呼吸連鎖におけるエネルギー変換の 重要な分子設計原理を明らかにしています

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
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