インタールイウキン-13は,筋の代謝状態を,耐久運動へと導く
Nelson H Knudsen1, Kristopher J Stanya1, Alexander L Hyde1
1Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Science (New York, N.Y.)
|May 2, 2020
まとめ
運動は筋肉のインタールイキン-13 (IL-13) を誘発し,燃料の節約と代謝の適性を高めます. このサイトカインは 運動の適応や 耐久性や 血糖のコントロールの改善に不可欠です
科学分野:
- 免疫学
- 運動 生理学
- 代謝の調節
背景:
- 運動訓練は筋肉のミトコンドリア機能と代謝能力を高めます
- 運動とこれらの適応を結びつける 分子機構は 完全に理解されていません
研究 の 目的:
- 運動による骨格筋の代謝適応を媒介するインタールイキン-13 (IL-13) の役割を調査する.
- IL-13が作用するシグナル伝達経路を解明する.
主な方法:
- IL-13 を欠いた遺伝子組み換えマウス (Il13 マウス) と対照群を用いた.
- ランニング耐久性,ミトコンドリア呼吸能力,グルコース耐性を評価した.
- IL-13受容体アルファ1 (IL-13Rα1) とシグナルトランスデューサーおよびトランスクリプションアクティベーター3 (Stat3) による下流信号伝達が調査された.
主要な成果:
- 運動は野生型のマウスでIL-13を誘発し,脂肪酸の酸化とグリコゲンの保存を促進した.
- II13マウスはミトコンドリアの生体生成が低下し,走行耐久性が低下し,対照群と比較してグルコース耐性が低下した.
- 外因的なIL-13投与または強化されたIL-13シグナリングは,耐久性および代謝に対する運動効果を模倣した.
- 筋肉のIL- 13Rα1またはStat3の遺伝的消去は,運動による走行能力の改善を無効にしました.
結論:
- インタールイキン-13 (IL-13) は,運動による骨格筋の代謝適応の主要な媒介体である.
- IL-13は燃料利用とミトコンドリア機能を調整し,筋肉の燃料効率を高める.
- IL-13 / IL-13Rα1 / Stat3経路は,運動能力と代謝効果に不可欠です.
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