レムデシビルによるSARS-CoV-2によるRNA依存性RNAポリメラーゼの抑制の構造的基礎

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Updated: Dec 22, 2025

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
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Published on: May 5, 2014

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Wanchao Yin1,2, Chunyou Mao2, Xiaodong Luan3,4,5

  • 1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Science (New York, N.Y.)
|May 3, 2020
PubMed
まとめ

SARS-CoV-2のRNA依存RNAポリメラーゼの構造分析は,レムデシビルがウイルス複製を抑制する方法を明らかにしています. クリオ-EM構造は,COVID-19に対する新しい抗ウイルス薬の設計のためのテンプレートを提供します.

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