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Updated: Dec 22, 2025

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
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非従来の細胞外チャペロンによるアルファシヌクレイン膜毒性の抑制のための分子機構

Rashik Ahmed1, Jinfeng Huang2, Daniel K Weber3

  • 1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton ON L8S 4M1, Canada.

Journal of the American Chemical Society
|May 9, 2020
PubMed
まとめ

ヒト血清アルブミン (HSA) は,パーキンソン病 (PD) のアルファシヌクレイン (αS) オリゴーマー毒性を,多段階のメカニズムによって抑制する. HSAは有毒なαSオリゴーマーを標的にし,それらをより有害な形態に改造し,細胞膜との相互作用をブロックします.

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