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Updated: Dec 22, 2025

Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion
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ヒトの重複膨張疾患における転写凝縮物の非混合

Shaon Basu1, Sebastian D Mackowiak1, Henri Niskanen1

  • 1Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.

Cell
|May 11, 2020
PubMed
まとめ

転写因子 (TFs) のアミノ酸の繰り返し拡張は遺伝的障害を引き起こす. これらのTFの相分離が変化すると,細胞機能が乱され,病気のメカニズムが説明される可能性がある.

キーワード:
アクティベーション領域コンデンサ本質的に無秩序な地域段階分離拡張を繰り返すシンポリダクティリア転写因子トランスクリプション コンデンサート

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