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多世代伝染の免疫的モードが腸内特ゲのセットポイントを制御する
Deepshika Ramanan1, Esen Sefik1, Silvia Galván-Peña1
1Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Cell
|May 14, 2020
まとめ
母親は新しい非遺伝的経路で 腸内免疫セットポイントを伝達します この母性免疫伝播は,世代を超えてRORγ+ 調節性T細胞の割合とIgAの産生に影響を与えます.
科学分野:
- 免疫学
- 微生物学
- 遺伝学
背景:
- 免疫は 保護成分を伝達することに 依存しています
- RORγを発現する調節性T細胞 (Tregs) は,腸内炎症の制御に不可欠です.
- 免疫系のセットポイントの伝播は完全に理解されていません.
研究 の 目的:
- 免疫系のセットポイントの 伝播を調査する
- 腸の免疫を調節する母親の役割を理解する
- 免疫特性の世代間移転を調査する
主な方法:
- 同性愛マウスのRORγ+ Treg比率を研究した.
- 出産後の特定の年齢のウィンドウで母性感染を調査した.
- 分析されたIgAの産生と腸の開始層との相関関係.
- エントロ乳腺軸経由のフィードバックループモデルを提案した.
主要な成果:
- RORγ+ Tregのセットポイントの非遺伝的,非表遺伝的,非微生物的伝播が発見されました.
- RORγ+ Tregの比率は,母から受け継がれ,生涯にわたって安定し,混乱に耐える.
- これらのTregの比率は,IgAの産生と腸内共生層と負の相関関係にある.
- エントロ・ママリー軸経由の 世代間伝播を特定した
結論:
- 多世代伝染の新種の免疫学的な方法が存在する.
- この伝播は腸の免疫反応と炎症性疾患に対する感受性に影響します.
- この世代間の免疫プログラムにおいて エントロ・ママリー軸は重要な役割を果たします
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