食物への非光学的な誘導を誘導する網膜内定のチューン回路
Diego Carlos Fernandez1, Ruchi Komal2, Jennifer Langel2
1National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA. diego.fernandez@nih.gov.
Nature
|May 15, 2020
まとめ
早期の視覚系の発達は,昼夜リズムが食事スケジュールに組み込まれるのに不可欠です. 本質的に光敏感な網膜のギャングリア細胞 (ipRGCs) は,発達の過程でIGL-SCN回路に影響を与えることで,餌時間反応を形作ります.
科学分野:
- 神経科学
- クロノバイオロジー
- 発達生物学
背景:
- 日常の光や食べ物の影響を受けます
- これらのシグナルを統合する神経回路は,完全に理解されていません.
- 本質的に光に敏感な網膜のギャングリア細胞 (ipRGCs) は光学情報を上皮質核 (SCN) と内皮質内皮質 (IGL) に伝達する.
研究 の 目的:
- 網膜のインプットが,時間制限の餌のような非光学的なシグナルに誘導するかどうかを調べる.
- IGL-SCN回路の形成における産後早期のipRGC内置の役割を決定する.
主な方法:
- 生後初期に ipRGC が欠けていた成人のマウスを使用した.
- 遅い段階のipRGC消去の効果を調べた
- 成人マウスの神経ペプチドY (NPY) を発現するIGLニューロンを静止した.
- 食品を予想する活動が評価されています
主要な成果:
- 初期段階のipRGCが欠けていたマウスは,時間制限の食事への誘導に障害を示した.
- ipRGCの消去は有意な効果を示さなかった.
- 早期のipRGC内置は,IGL NPYニューロンに影響を与え,IGL-SCN回路組立を誘導する.
- IGL NPYニューロンを静止させると,初期のipRGC消去の欠陥を模倣した.
- SCNのIGL NPY端末を阻害すると,食物予期活性が低下する.
結論:
- IGL-SCN回路が時間制限の餌に誘導される能力を確立するために,早期の産後ipRGC内置は不可欠です.
- ipRGCの影響による発達のタイミングは,非光学的昼夜信号の引き寄せに極めて重要です.
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