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病理 生理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理
April W Armstrong1, Charlotte Read1,2
1Keck School of Medicine, Department of Dermatology, University of Southern California Los Angeles.
JAMA
|May 20, 2020
まとめ
牛皮病は全世界で 1億2,500万人に感染し 深刻な健康問題を引き起こしています 特定のサイトカインを標的とした新しい生物学的治療法は,中等度から重度のプラーク型牛皮病に対する先進的な選択肢を提供し,患者の生活の質を改善します.
科学分野:
- 皮膚科と免疫科
- 炎症性皮膚疾患
- 併発性研究
背景:
- 牛皮病は慢性的な炎症性皮膚疾患で 世界中で約"億2,500万人が罹患しています
- 牛皮質関節炎,心臓代謝疾患,精神疾患など,かなりの罹患率と関連しており,生活の質を著しく低下させている.
- 最も一般的な形態であるプラーク型牛皮病は 病原性,遺伝,併発性,治療の理解が急速に進歩しています
研究 の 目的:
- プラーク型牛皮病の理解と治療の現状を 検討する.
- 中等から重度のプラーク型牛皮病の 生物学的および口腔療法における進歩を強調する.
- 併発症の管理の重要性を強調する.
主な方法:
- プラーク型牛皮病の病原性,遺伝,および併発性に関する現在の文献のレビュー.
- 確立されたガイドラインに基づいて,局所的,生物学的,および口腔治療の選択肢の分析.
- 様々な治療薬の有効性と安全性に関する分析
主要な成果:
- 局所薬は,軽度の牛皮病の主要な治療法です.
- 腫瘍死因アルファ (TNF-α),IL-12/23,IL-17,およびIL-23を標的とした生物学的治療法は,中度から重度のプラーク型牛皮病に有効です.
- TNF-α,IL-12/23,およびIL-17を標的とする生物学的薬剤も,牛皮質関節炎の治療に示されています.
結論:
- 牛皮病は複雑な炎症性疾患で 重要な全身的影響を及ぼします
- 局所治療は軽度の症例の基礎であり,高度な生物学的薬剤と経口薬剤はより重症な疾患の治療における重要な進歩を表しています.
- 牛皮病の管理には,皮膚症状と関連する併発症の両方に対処する包括的なアプローチが必要で,患者の治療結果と生活の質を向上させる必要があります.
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