薄さによるALKの識別
Michael Orthofer1, Armand Valsesia2, Reedik Mägi3
1IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna 1030, Austria.
Cell
|May 23, 2020
まとめ
研究 者 たち は アナプラスティック リンパ腫 キナーゼ (ALK) を 痩せ に 寄与 する 重要な 遺伝子 と し て 特定 し まし た. この遺伝子は体重を調節し 肥満に抵抗する役割を果たします
科学分野:
- 遺伝学
- メタボリズム
- 神経科学
背景:
- 体重増加に対する個々の感受性は大きく異なります.
- 肥満 研究 は,肥満 に 関する 遺伝 的 傾向 に 注目 し て い ます が,痩せ て しまう 原因 を 見過ごし て い ます.
研究 の 目的:
- 健康的な体型を維持する遺伝子を 特定するためです
- アナプラスティックリンパ腫キナーゼ (ALK) が体重を調節し,肥満を予防する役割を調査する.
主な方法:
- エストニアの代謝的に健康な薄型コホートにおける全ゲノム関連研究 (GWAS).
- ドロソフィラの遺伝子破壊研究とマウスの遺伝子消去研究
- 視床下部の神経細胞と交感神経系の脂肪組織におけるALKの役割の調査.
主要な成果:
- アナプラスティックリンパ腫キナーゼ (ALK) は,痩身のための候補遺伝子として特定されました.
- ドロソフィラのアルクのノックダウンにより,トリグリセリドのレベルが低下した.
- マウスにおけるアルクの遺伝的欠失は,痩せられ,食生活やレプチン変異による肥満に対する抵抗性をもたらした.
- 下垂体ニューロンのALKは,脂肪組織の脂解の同情的制御を通じてエネルギー消費を調節する.
結論:
- アナプラスティックリンパ腫キナーゼ (ALK) は,健康的な痩せた体重を維持する重要な要因です.
- ALKは視床下部でエネルギー消費と脂質分解を制御し,体重増加に抵抗します.
関連する概念動画
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