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Updated: Dec 20, 2025

Incorporating Pericytes into an Endothelial Cell Bead Sprouting Assay
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フォスフォノシチド3キナーゼによるペリサイト成熟が血管再構成を制御する

Ana M Figueiredo1, Pilar Villacampa1, Rodrigo Diéguez-Hurtado2

  • 1Vascular Biology and Signalling Group, ProCURE, Oncobell Program, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL), Gran Via de l'Hospitalet 199, 08908 L´Hospitalet de Llobregat, Barcelona, Spain (A.M.F., P.V., P.K., A.M.-R., A.A.-U., M.G.).

Circulation
|May 30, 2020
PubMed
まとめ

フォスフォノシチド3キナーゼβ (PI3Kβ) の活動により,血管形成中の細胞の成熟が制御されます. PI3Kβを阻害すると,適切な血管新生に不可欠なペリサイトの成熟が加速し,潜在的に新しい治療標的が提供されます.

キーワード:
血管新生,生理学的ペリサイトフォスホイノシチド3キナーゼ信号変換

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