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人間の腫瘍微生物群は,腫瘍型に特化した細胞内細菌で構成されている.

Deborah Nejman ¹, Ilana Livyatan ^1,2, Garold Fuks ³

¹Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
²Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
³Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.
⁴Division of Surgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
⁵Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
⁶Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
⁷Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel.
⁸Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁹Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.
¹⁰Orthopaedic Pathophysiology and Regenerative Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
¹¹Department of Bioinformatics, Jerusalem College of Technology, Jerusalem, Israel.
¹²Translational Medicine, Oncology R&D, AstraZeneca, Gaithersburg, MD, USA.
¹³Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
¹⁴Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
¹⁵Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.
¹⁶Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel.
¹⁷Department of Thoracic Surgery, Sheba Medical Center, Ramat Gan, Israel.
¹⁸Department of Medical Oncology and Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
¹⁹Pediatric Gastroenterology Institute, Rambam Medical Center, Haifa, Israel.
²⁰Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
²¹Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.
²²Division of General Surgery, Rambam Health Care Campus, Haifa, Israel.
²³Ambulatory and Breast Surgery Service, Rambam Health Care Campus, Haifa, Israel.
²⁴Department of Thoracic Surgery, Rambam Health Care Campus, Haifa, Israel.
²⁵Department of Neurosurgery, Sheba Medical Center, Ramat Gan, Israel.
²⁶Department of Neurosurgery, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
²⁷Neuro-Oncology Unit, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
²⁸Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel.
²⁹Breast Oncology Institute, Sheba Medical Center, Ramat Gan, Israel.
³⁰Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
³¹Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
³²Department of Surgical Oncology (Surgery C), Sheba Medical Center, Ramat Gan, Israel.
³³Department of Pathology, Sheba Medical Center, Ramat Gan, Israel.
³⁴Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
³⁵Division of Thoracic Surgery, City of Hope Medical Center, Duarte, CA, USA.
³⁶Department of Mathematics and Computer Science, The Open University of Israel, Ra'anana, Israel.
³⁷Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. ravidst@weizmann.ac.il.

⁰Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Clinical Neuroscience (new York, N.y.) +

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2020年5月30日

PubMedで要約を見る

まとめ

ヒト腫瘍の微生物群は研究が難しいものの癌の種類によって変化しており乳がんには豊富な細菌の多様性があります腫瘍内細菌は細胞内であり,腫瘍の特徴と治療反応と相関しています.

科学分野

腫瘍学
微生物学
ゲノミクス

背景

ヒトの腫瘍の中に細菌が存在することが一世紀以上前に確認されました
腫瘍の微生物群を特徴づけるのは,その低バイオマスのため難しい.

研究の目的

多様な癌の微生物群を総合的に分析する
腫瘍内の細菌の組成と特性を調べる

主な方法

7種類の癌の1526の腫瘍と隣接する正常な組織を分析した.
微生物の組成,細菌の位置 (細胞内),および臨床データとの相関性を調査した.

主要な成果

腫瘍の種類はそれぞれ微生物群の特徴があります
乳がんは特に豊かで多様な腫瘍微生物群を示しています
腫瘍内細菌は主に細胞内であり,癌細胞と免疫細胞に存在していました.
腫瘍内細菌,腫瘍サブタイプ,喫煙状態,免疫療法への反応との間には相関関係が見られた.

結論

腫瘍の微生物群は複雑で癌のタイプに特異的な存在です
腫瘍内細菌は,腫瘍の生物学と治療結果に影響を与える潜在的な要因です.

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