ニューヨーク市地域におけるSARS-CoV-2の導入と早期の拡散
Ana S Gonzalez-Reiche1, Matthew M Hernandez2,3, Mitchell J Sullivan1
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
まとめ
重症急性呼吸器症候群コロナウイルス2 (SARS-CoV-2) の複数の感染がニューヨーク市で急速な感染拡大を助長した. 初期のゲノム分析では 都市近隣の様々な患者集団によるコミュニティ感染が 明らかになった.
科学分野:
- ウイルス学
- ゲノミクス
- エピデミオロジー
背景:
- ニューヨーク市は重症急性呼吸器症候群新型コロナウイルス2型 (SARS-CoV-2) パンデミックの主な拠点となりました.
- 早期の感染を把握することは 都市部でのウイルスの拡散を制御する上で 極めて重要です
研究 の 目的:
- ニューヨーク市におけるSARS-CoV-2の起源と早期の感染動態を調査する.
- NYC都市部で流通しているSARS-CoV-2株の遺伝的多様性を分析する.
主な方法:
- 重症急性呼吸器症候群コロナウイルス2 (SARS-CoV-2) ゲノム84の系統分析.
- マウント・シナイ・ヘルス・システムの 患者のウイルスのシーケンス
主要な成果:
- 主にヨーロッパや他の米国地域から,NYCにSARS-CoV-2が独立して複数導入されたことが確認されました.
- コミュニティでの感染の証拠を検出した. 関連するウイルスの株は, 異なる街区の患者で発見された.
- 伝染病の早期拡散を追跡する際にウイルスのゲノミクスの有用性を示した.
結論:
- NYCでのSARS-CoV-2の急速な拡散は,複数の独立した導入によって引き起こされました.
- コミュニティでの伝播は,都市内のウイルスの早期の拡散に重要な役割を果たしました.
- ゲノム監視は パンデミック発生の理解と管理に不可欠です
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