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Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
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癌の負荷は,腫瘍細胞との壁細胞β3-インテグリン調節されたクロストークによって制御されます

Ping-Pui Wong1, José M Muñoz-Félix2, Maruan Hijazi3

  • 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; Centre for Tumor Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.

Cell
|May 31, 2020
PubMed
まとめ

血管だけでなく 壁の細胞も 腫瘍の成長に影響します 壁細胞のβ-3インテグリンの喪失は,がん細胞の生存と増殖を促進するシグナルを送ることによって,腫瘍の拡大を促進します.

キーワード:
壁の細胞パラクリンβ3インテグリン

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