癌患者に対するCOVID-19の臨床効果 (CCC19):コホート研究
Nicole M Kuderer1, Toni K Choueiri2, Dimpy P Shah3
1Advanced Cancer Research Group, Kirkland, WA, USA.
Lancet (London, England)
|June 1, 2020
まとめ
癌患者のCOVID-19の死亡率は高い. 高齢,男性性,併発性,がんは 30日間の死亡リスクを増加させる. 地理的な位置も結果に影響します
科学分野:
- 腫瘍学
- 感染症
- 流行病学
背景:
- COVID-19と診断されたがん患者のアウトカムに関するデータは限られている.
- これらのアウトカムを特徴づけることは,予後要因を特定するために極めて重要です.
研究 の 目的:
- COVID-19 がん患者のアウトカムを特徴づけること.
- この集団における死亡率と重症疾患の予後要因を特定する.
主な方法:
- コホート研究では,CCC19データベース (米国,カナダ,スペイン) の非特定データを分析した.
- 18歳以上でSARS-CoV-2感染が確認され,悪性腫瘍が進行している患者も含まれています.
- 主なエンドポイントは,物流回帰を用いて分析された30日間の全原因死亡率でした.
主要な成果:
- 928人の患者は入院基準を満たし,13%は30日以内に死亡しました.
- 死亡率の独立予測因子には,高齢者,男性,喫煙歴,併発性疾患,不良パフォーマンス状態,がんが含まれる.
- アジトロマイシンとヒドロキシクロクインの投与は死亡率の増加と関連していた (混同の可能性).
結論:
- COVID-19 がん患者の30日間の死亡率は高い.
- 死亡率は一般的な危険因子と 癌特有の危険因子とも関連しています
- 長期的な効果と治療の影響を理解するためにさらなるフォローアップが必要である.
関連する概念動画
01:21Cancer Survival Analysis
578
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
578
02:49Cancer Therapies
9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
01:03Rous Sarcoma Virus (RSV) and Cancer
6.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.0K
02:56Treatment Resistant Cancers
3.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K
02:43Mouse Models of Cancer Study
6.3K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.3K
01:19Psychoneuroimmunology: Diabetes and Cancer
357
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
357