早期 心臓 改造 は 腫瘍 の 成長 と 転移 を 促進 する
Shimrit Avraham1,2, Soraya Abu-Sharki1,2, Rona Shofti1
1Department of Cell Biology and Cancer Science (S.A., S.A.-S., R.K., T.F., Y.S., A.A.), Rambam Medical Center, Haifa, Israel.
Circulation
|June 2, 2020
まとめ
早期の心臓改造は 圧力の過剰に起因し 癌の増殖と転移を促します 心臓病の治療は,ペリオスティンのような腫瘍促進因子を減らすことで,がんのアウトカムを改善する可能性があります.
科学分野:
- 心臓病科
- 腫瘍学
- 翻訳医学
背景:
- 心血管疾患と癌は 相互に関連していると認識されつつあります
- 化学療法による心臓毒性および心不全/ストレスと癌の予後不良との関連が確立されています.
- 心不全とは無関係な早期心改造が がん進行における役割は不明である.
研究 の 目的:
- 腫瘍の成長と転移に対する 早期の心臓改造の影響を調査する
- 腫瘍を誘発する環境を作り出せるか 判断する
主な方法:
- マウスにおける横軸大動脈収縮 (TAC) を利用して,圧力過負荷による心筋縮をモデル化した.
- 腫瘍の成長と転移を評価するために,TAC操作されたマウスに癌細胞を埋め込みました.
- 腫瘍促進媒体を特定するために,血清因子と遺伝子発現 (RNA配列) を分析した.
主要な成果:
- TAC手術を受けたマウスは,増殖率と転移性病変を伴うより大きな原発性腫瘍を示した.
- TACマウスの血清は,分泌された因子を示す,がん細胞の増殖をインビトロで強化した.
- ペリオスティンmRNAと血清濃度はTACマウスで上昇し,ペリオスティンの減少は癌細胞の増殖を減少させ,添加は増幅した.
結論:
- 早期の心臓改造は 腫瘍の成長と転移を大きく促進し 全体的な癌の進行を促します
- ペリオスティンは,心臓リモデルのプロトゥモリジェニック効果を媒介する重要な分泌因子として特定されています.
- 早期発見と治療は,がんの進行を弱め,患者の治療結果を改善するために不可欠です.
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