若年成人における単発性シストリックまたはダイアストリック高血圧の心血管リスク
Hokyou Lee1,2, Yuichiro Yano3, So Mi Jemma Cho4
1Departments of Preventive Medicine (H.L., H.C.K.), Yonsei University College of Medicine, Seoul, Korea.
Circulation
|June 2, 2020
まとめ
統合失調症 (ISH),統合失調症 (IDH),統合失調症および統合失調症 (SDH) を含む若年成人における第1段階の高血圧は,すべて心血管疾患 (CVD) のリスクを高めます. SDHはこれらのサブタイプの中で最も高いリスクを持ち,正確なリスクの分層化の必要性を強調しています.
科学分野:
- 心臓病科
- 公衆衛生
- 高血圧 研究
背景:
- 若年成人における異なるステージ1の高血圧に関連する心血管疾患 (CVD) のリスクに関する理解は限られている.
- 2017年のACC/AHAの血圧 (BP) ガイドラインは高血圧の段階を定義しているが,若年層における孤立した静脈動脈高血圧 (ISH),孤立した静脈動脈高血圧 (IDH),および静脈動脈動脈高血圧 (SDH) のアウトカムはまだ不明である.
研究 の 目的:
- ステージ1の高血圧と若年成人におけるCVDイベントの関連性を調査する.
- 高血圧,第1段階のIDH,第1段階のISH,第1段階のSDH,第2段階の高血圧のCVDリスクと正常血圧を若い集団で比較する.
主な方法:
- 抗高血圧薬を使用していない20~39歳の640万人以上の参加者を含む全国の健康診断データベースの分析.
- 参加者は正常血圧,高血圧,第1ステージIDH,第1ステージISH,第1ステージSDH,第2ステージ高血圧のグループに分けられました.
- 複合CVDイベント (心筋梗塞,脳卒中,心不全,CVD関連死亡) は,平均13. 2年の追跡期間で追跡されました.
主要な成果:
- ステージ1の高血圧 (ISH,IDH,SDH) のすべての形態は,若年成人における正常血圧と比較して,心血管疾患のリスクの増加と関連していました.
- ステージ1のSDHは,ステージ1のISH (HR 1.36) とステージ1のIDH (HR 1.32) よりも著しく高いCVDリスクを示した.
- ステージ2の高血圧は最高心血管疾患リスク (HR2. 40) であり,高血圧も顕著に増加した (HR1. 14).
結論:
- ステージ1のISH,IDH,SDHは,若年成人における心血管疾患のリスク上昇と関連しています.
- ISH,IDH,SDHを区別することは,リスクの正確な分層化と,高リスクの若者を特定するために不可欠です.
- この発見は,長期的なCVDのアウトカムを緩和するために,高血圧の早期管理の重要性を強調しています.
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