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Updated: Dec 19, 2025

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
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A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells

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A-改変mRNAを調節するYTHDFタンパク質の機能に関する統一モデル

Sara Zaccara1, Samie R Jaffrey1

  • 1Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.

Cell
|June 4, 2020
PubMed
まとめ

N6-メチラデノシン (m6A) RNAの改変は細胞の分化を調節する. 以前は異なるmRNAを結合すると考えられていたYTHDFタンパク質は,実際には同じmRNAを結合し,mRNAの分解と分化を冗長的に媒介する.

キーワード:
トランスレーション,mRNAの安定性,m(6) A,METTL3,YTHDF1,YTHDF2,YTHDF3,CLIP,RNA結合

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