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Updated: Dec 19, 2025

Analyses of Mitochondrial Calcium Influx in Isolated Mitochondria and Cultured Cells
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Analyses of Mitochondrial Calcium Influx in Isolated Mitochondria and Cultured Cells

Published on: April 27, 2018

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ミトコンドリアCa2+ユニポーターホロコンプレックス構造とメカニズム

Minrui Fan1, Jinru Zhang1, Chen-Wei Tsai2

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|June 5, 2020
PubMed
まとめ

研究者はヒトのミトコンドリアのカルシウムユニポーター複合体を視覚化し,MICUタンパク質がカルシウム吸収をどのように調節するかを明らかにしました. これは,ミトコンドリアカルシウム処理と潜在的な疾患治療を理解するための枠組みを提供します.

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The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
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