母乳は世代を超えた免疫遺伝を調節する
Jakob Zimmermann1, Andrew J Macpherson1
1Maurice Müller Laboratories (Department for BioMedical Research), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3008 Bern, Switzerland.
Cell
|June 5, 2020
まとめ
母親の母乳,特に免疫グロブリンAは,出生後のROR-γt+ 調節性T細胞 (Tregs) を遺伝的に制御しない. この免疫グロブリンAの遺伝は,ROR-γt+ Tregsによって大腸炎症と病原体のクリアランスに影響を与えます.
科学分野:
- 免疫学
- 微生物学
- 発達生物学
背景:
- ROR-γt+ 調節性T細胞 (Tregs) は結腸の炎症と病原体に対する防御を均衡させる.
- ROR-γt+ Tregの機能を規制するメカニズムは,ほとんど不明である.
研究 の 目的:
- ROR-γt+ Tregのセットポイントと機能を制御する非遺伝的要因を解明する.
- 新生児の免疫系の発達に対する母親の貢献を理解する.
主な方法:
- ROR-γt+ Tregの発達における母性因子の役割を調査した.
- 免疫グロブリンA (IgA) を母性遺伝の研究の主要な焦点として利用した.
- 生後免疫プログラムに関する 重要な時間枠を調べた
主要な成果:
- ROR-γt+ Tregのセットポイントの重要な要因として,遺伝的でない母性遺伝を特定した.
- 母乳中の免疫グロブリンAが この遺伝を媒介することを示した.
- 母親のIgA経由で免疫プログラムが作られる 生後期を決定した.
結論:
- 母乳を通して伝達される母親の免疫グロブリンAは,ROR-γt+ Tregsのプログラム化に不可欠です.
- 炎症と病原体のクリアランスに影響を与えます
- このメカニズムを理解することで 早期の免疫発達や 潜在的な介入の洞察が得られます
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