フィードバックは視覚野のニューロンで 2つ目の受容場を生成します
Andreas J Keller1,2, Morgane M Roth3,4, Massimo Scanziani5,6
1Department of Physiology, University of California San Francisco, San Francisco, CA, USA. andreasjakob.keller@ucsf.edu.
Nature
|June 6, 2020
まとめ
研究者はマウスの視覚野にフィードバック受容場 (fbRF) を発見し,古典的なフィードフォワード受容場 (ffRF) を補完した. このfbRFは 刺激の予測と処理を強化するために 視覚的な文脈を使用します
科学分野:
- 神経科学
- 視覚システム処理
- 感覚神経科学
背景:
- 感覚経路は臓器と脳を結びつけ,刺激刺激のための古典的受容場 (ffRF) を定義する.
- ニューロンは ffRF 以外の刺激によって刺激され,文脈に依存した処理が示唆されるが,そのメカニズムは不明である.
研究 の 目的:
- クラシックな前向き受容場 (ffRF) 以外の刺激によって神経刺激を生成するメカニズムを解明する.
- マウスの視覚皮質で新たに確認されたフィードバック受容場 (fbRF) を特徴づける.
主な方法:
- マウスの主視野皮質の刺激性ニューロンへのフィードバック投影を調査した.
- 反応特性を比較するために ffRFとfbRFの両方を刺激した.
- 反応の調節を評価するために,麻酔と高い視覚領域の静止を活用した.
- フィードバック入力と皮質層の間のニューロンの位置の受容場特性を調べた.
主要な成果:
- フィードバック・プロジェクションは, ffRF の外の刺激によって誘発される第二の受容場 (fbRF) を生み出します.
- ffRF刺激と比較して,fbRF刺激は遅い,遅い反応を誘発する.
- 反応は麻酔と上部視野の静止によって減少します.
- fbRFとffRFは相互に敵対しており,特定の抑制性ニューロン集団は異なる反応を示しています.
結論:
- fbRFは ffRFを補完し,ニューロンが予測処理のために視覚的文脈を使用することを可能にします.
- フィードバックプロジェクションは,欠けている情報を推定し,視覚空間における刺激特性の違いを検出するのに役立ちます.
- fbRFメカニズムは,視覚システムに文脈情報を統合するために不可欠です.
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