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Updated: Dec 19, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

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協同性による選択性:半合成天然製品との相互作用の好ましい安定化

Madita Wolter1, Pim de Vink1, João Filipe Neves2,3

  • 1Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Technische Universiteit Eindhoven, P.O. Box 513, Eindhoven 5600 MB, The Netherlands.

Journal of the American Chemical Society
|June 6, 2020
PubMed
まとめ

合成タンパク質相互作用 (PPI) 安定剤は十分に研究されていない. この研究では,p65/14-3-3複合体を選択的に安定させ,新しい薬剤発見アプローチを提供する半合成派生剤DP-005を導入しました.

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