光酵素エナチオセレクティブ分子間基の水酸化
Xiaoqiang Huang1,2, Binju Wang3,4,5, Yajie Wang1,2
1Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Nature
|June 9, 2020
まとめ
この研究は,可視光光触媒を用いたキラルカルボニル化合物の合成のための新しい酵素触媒反応を導入する. この方法は,効率的な分子間基質水酸化を可能にし,バイオカタリシスの応用を拡大します.
科学分野:
- 生物触媒と有機合成
- 光触媒
- 酵素工学
背景:
- 非対称合成における酵素の適用は,自然に発生する反応によって制限されます.
- 光触媒は既知の酵素の新たな反応性を明らかにした.
- 光誘発酵素触媒は,分子間クロスカップリング反応に適用されていません.
研究 の 目的:
- "エネ"還元酵素によって触媒化された,可視光誘導の新種の分子間基質水酸化を開発する.
- γ-ステレオセンターでキラルカルボニル化合物を合成する.
- 酵素光反応とステレオ化学制御の課題を克服するために
主な方法:
- 可視光誘発のラジカル水アルキル化のために"エネ"リダクタスを利用した.
- 簡単に手に入るα-ハロカルボニル化合物と末端アルケンを基板として使用した.
- 基質-酵素複合体の形成によるメカニズム的経路の調査.
主要な成果:
- γ-ステレオセンターで様々なカルボニル化合物の効率的な合成を達成した.
- 優れた収穫率 (最大99%) とエナチオ選択性 (最大99%) が得られた.
- 化学触媒を用いて以前は達成できなかった方法を示した.
結論:
- 開発された方法は,非対称な変換のための生物触媒の反応性を拡張します.
- 光触媒と酵素触媒の融合により 新しい合成経路が生まれます
- 酵素と基質の複合体の形成によって誘発される.
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