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Updated: Dec 18, 2025

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
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NPC1およびNPC2による低pH依存性ライソソーマルコレステロールエグレスの構造的基礎

Hongwu Qian1, Xuelan Wu2, Ximing Du3

  • 1Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Cell
|June 17, 2020
PubMed
まとめ

NPC1およびNPC2タンパク質の欠陥は,ニーマン・ピック病C型 (NPC) を引き起こします. この研究は,低pHでNPC2からNPC1へのコレステロールの移転のメカニズムを明らかにし,リゾソームのコレステロール排出に不可欠です.

キーワード:
NPC1 についてNPC2 についてニーマン・ピック病C型コレステロール輸送クリオ・エム溶解体コレステロールの脱出構造生物学

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