関連する実験動画

Updated: Dec 17, 2025

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
06:17

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay

Published on: February 28, 2025

996

近接活性療法による共性タンパク質薬の開発

Qingke Li1, Qu Chen2, Paul C Klauser3

  • 1Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Hangzhou Research Institute of Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Hangzhou 310018, China.

Cell
|June 25, 2020
PubMed
まとめ

研究者はPD-1に特別なアミノ酸を組み込むことで,共性タンパク質薬を作る新しい方法を開発しました. これはPD-L1への不可逆的な結合を可能にし,困難な疾患に対する強力な抗腫瘍効果を提供します.

キーワード:
遺伝子コードの拡張PERx についてSuFEx について生物反応性アミノ酸ガンに対する免疫療法クリック 化学結合タンパク質薬免疫チェックポイント近接式反応療法近接性による反応性硫黄フッ化物交換非自然のアミノ酸

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