コミュニティにおける大動脈の大きさ,動脈瘤,および解剖の家族的なクラスタリング
Jakob Raunsø1, Rebecca J Song2, Ramachandran S Vasan2,3,4
1Department of Cardiology, Herlev and Gentofte Hospital, Denmark (J.R., B.N.).
Circulation
|June 26, 2020
まとめ
家族歴は,大動脈動脈瘤と解剖のリスクを大幅に増加させます. 大動脈の拡張が家族に伝わるため,罹患者の一級親戚のスクリーニングが推奨されます.
科学分野:
- 心血管医学
- 遺伝学
- 公衆衛生
背景:
- 破裂した大動脈動脈と大動脈解剖は 生命を脅かす状態で 高い死亡率があります
- スクリーニングによる早期発見は 早期の介入を可能にし 死亡率を減らすことができます
- これらの条件の先駆者である大動脈拡張の家族的結合は不明である.
研究 の 目的:
- 胸部と腹部の大動脈の拡張の家族的リスクを調査する.
- 動脈動脈瘤の発生率と 罹患者の親戚の解剖率を推定する.
主な方法:
- フレミングハム心臓研究のコホートを使って 親の大動脈の大きさに基づいて 子宮の大動脈の大きさを評価しました
- デンマーク全国の行政登録を活用して,対照群と対照群の1級親族における大動脈動脈瘤と解剖の発生率を比較した.
主要な成果:
- 親が大動脈の大きさの上部四分位にある子には,大動脈の大きさが3倍になる確率は高かった.
- 動脈動脈瘤または解剖を患った個人の一級親族は,対照群と比較して,著しく高い危険比率 (動脈動脈瘤の6. 7%,解剖の9. 24) を示した.
- これらのリスクは,高血圧や双管大動脈弁などの併発性疾患を調整した後も一貫していました.
結論:
- 動脈瘤と解剖の予測要因である 大動脈の大きさは 血統的集団化を示しています
- 甲動脈瘤と解剖の発生率は,一般的な心血管疾患に匹敵する.
- 血動脈動脈瘤と血動脈解剖の系統的なスクリーニングは,これらの発見によって支持されています.
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