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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

592
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
592
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
211
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

604
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
604
Pancreas01:19

Pancreas

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The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
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臓がん

Jonathan D Mizrahi1, Rishi Surana1, Juan W Valle2

  • 1Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Lancet (London, England)
|June 29, 2020
PubMed
まとめ

臓がんの生存率は低く 症状は曖昧です CTスキャンによる早期発見や 化学療法や標的治療などの先進的な治療法により 治療結果が改善されます

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科学分野:

  • 腫瘍学
  • 胃腸内科

背景:

  • 臓がんは癌による死亡の主な原因で 5年生存率は低い.
  • 危険因子 に は,家族 の 病歴,肥満,第 2 型 糖尿病,喫煙 など が 含ま れ ます.
  • 曖昧な症状は 遅い段階で診断され 治療が難しくなります

研究 の 目的:

  • 臓がんの現在の診断方法とステージを 検討する.
  • 臓がんの異なる段階の治療戦略の概要を述べる
  • 新しい治療法を紹介するためです

主な方法:

  • 静脈内コントラストによる高品質のコンピュータ断層撮影 (CT) は検出と切除性の評価の鍵です.
  • 精細針吸入による内視超音波 (EUS) は,補完的なステージ設定と診断ツールとして機能します.
  • 患者の分類は切除可能な,切除可能な,局所的に進行した,または転移性疾患による治療決定です.

主要な成果:

  • 臓がんの唯一の治療法は 手術による切除です
  • 補助化学療法は長期的に改善しました.
  • FOLFIRINOXとゲムシタビンとナブパクリタキセルのような全身化学療法は,進行した病気の標準治療である.

結論:

  • PARP抑制はBRCA変異の患者にとって有望であり,標的治療への移行を示しています.
  • 腫瘍の微小環境の調節に関する研究は,免疫療法の有効性を高める可能性があります.
  • 手術,化学療法,新しい治療法を組み合わせた多分野アプローチは 臓がんの治療結果を改善するために不可欠です.