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Updated: Dec 16, 2025

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Pax5によるWapl抑制は,IghループエクストルーションによるV遺伝子再結合を促進する

Louisa Hill1, Anja Ebert1, Markus Jaritz1

  • 1Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.

Nature
|July 3, 2020
PubMed
まとめ

Pax5はプロB細胞でWaplを抑制し,免疫グロブリン遺伝子の再結合のためのクロマチンのループエクストルーションを可能にします. このプロセスは 免疫のための抗体の多様性を確保するために ゲノム構造を再構成します

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